Pathology Imaging and Informatics as the Cornerstone of Precision Medicine: Two years of Experience with the NIDDK Kidney Precision Medicine Project (KPMP)
The Kidney Precision Medicine Project is an ambitious, multi-year project funded by the NIDDK with the purpose of understanding and finding new ways to treat chronic kidney disease (CKD) and acute kidney injury (AKI). This will be accomplished by obtaining kidney tissue from KPMP participants, analyzing it using state-of-the-art technologies, and developing next generation software tools to visualize and share the resulting data. Pathology imaging and informatics plays a key role towards redefining kidney disease in molecular terms and identify novel targeted therapies.
About the Speaker:
Jeff Hodgin, MD, PhD
Assistant Professor of Pathology and Internal Medicine
University of Michigan
Dr. Hodgin received his PhD from the laboratory of Drs. Oliver Smithies and Nobuyo Maeda in the Department of Molecular and Cellular Pathology at the University of North Carolina in Chapel Hill in 2001, and his MD, also from UNC, in 2003. Dr. Hodgin completed residency training in Anatomic Pathology at Columbia University, New York, in 2006 and a Nephropathology Fellowship at Columbia University under the tutelage of Dr. Vivette D’Agati in 2008. As a fellow, he investigated genome-wide expression profiling of laser-captured glomeruli from renal biopsies of FSGS patients found in the extensive archives at Columbia. His experience there solidified a desire to focus his research and clinical career on diseases of the kidney, specifically glomerular diseases. Since joining the Department of Pathology at the University of Michigan in July of 2008, and working with Dr. Matthias Kretzler in Nephrology, Dr. Hodgin has added a systems biology approach to his interests and expertise. Since the inception of the Nephrotic Syndrome Study Network (NEPTUNE) over 10 years ago, he has been a member of the NEPTUNE Pathology Group and helped implement a standardized pathology scoring system to study structural-molecular-functional interactions for proteinuric glomerular diseases such as FSGS. More recently has joined the Kidney Precision Medicine Project (KPMP) as both Principle Investigator for a Tissue Interrogation Site, tasked with single cell RNA sequencing of human kidney biopsies, and as a Co-Investigator for the Central Hub as one of the kidney pathologists on the team working to create the KPMP Kidney Atlas. He now has more than 50 publications in both basic and translational research areas and has been funded though NIH and foundation grants as well as pharmaceutical agencies.
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About the Seminars:
This new webinar series brings together two successful organizations with a common goal of improving and disseminating the knowledge of glomerular kidney diseases. The Renal Pathology Society promotes excellence in diagnosis and research and encourages training and education in renal disease to its members around the world. This series’ curriculum focuses on research in renal pathology and new technologies applied to renal pathology, including image analytics, machine learning, multi-‘omics, and computational pathology approaches to renal biopsy analyses. Through this collaboration with GlomCon, the RPS is committed to promoting excellence in the diagnosis of glomerular disease and to bringing the breakthrough innovations in this field to the GlomCon community, which as of May 2019 represents more than 2200 clinicians and pathologists from 108 countries.